Abstract:Introduction: Type 2 diabetes mellitus (T2DM) is a rapidly growing chronic health problem, and the accompanying long-term microvascular and macrovascular complications cause significant morbidity and mortality in patients with diabetes. The aim of this study was to examine the effects of a 6-month intensive lifestyle modification intervention on metabolic parameters and relationship with cardiovascular disease in patients with type 2 diabetes mellitus. Materials and Methods: One hundred and twenty two patients were analyzed in this study. Of them 63 were control and 59 were study subjects (Intervention group). It was a cross-sectional study and retrospective in nature.data was collected from BIRDEM Hospital in Bangladesh. Results: Lifestyle modification intervention group patients showed a significant reduction in HbA1c, fasting blood glucose, and 2h PPG after 6 months. Differences between groups in changes of fasting serum glucose, fasting serum glucose after 30 minutes, 2h ABF, and HbA1c were also significant at 3 months. For total cholesterol, HDL-C, LDL-C, serum triglyceride concentrations and HOMAIR, the differences in changes between the intervention and control groups from baseline to the end of the study were small and not statistically significant. Conclusions: In conclusion, a 6-month lifestyle modification intervention in Bangladeshi type 2 diabetic patients resulted in improved glycemic control and early prevention of diabetes.