Clinical Science The Annual Scientific Meeting of the Australian Diabetes Society and the Australian Diabetes Educators Association 2013

GP CME Eligible Session

• (Not too) Sweet young things. Metabolic disease, youth and antipsychotics. - Katherine Samaras
• Life-Stage Appropriate Care for Young Adults with Type 1 Diabetes - Katherine Kibbey
• Prader Willi Syndrome: management - Tania Markovic
• Cystic Fibrosis - Glynis Ross

• A Multiethnic study of diabetic retinopathy: poorer outcomes continue for Australian Aborigines and Pacific Islanders - Maria Constantino
• Ultra-Wide-Field Retinal Photography: Implications for Detection, Treatment and Study of Diabetic Retinopathy - Belinda Brooks
• Short-term dietary salt supplementation is not associated with reduced renal function in hypertensive subjects with type 2 diabetes mellitus - Angela X Chen
• Change in prevalence and associates of CKD in type 2 diabetes: The Fremantle Diabetes Study - Wendy A Davis
• Renal structure in normoalbuminuric and albuminuric patients with type 2 diabetes and impaired renal function - Elif I Ekinci
• A Comparison of Insulin Requirements in Women with Type 1 and Type 2 Diabetes During Pregnancy - Suja Padmanabhan

• Accreditation of Diabetes Centres – the NADC application process  - Margaret McGill
• A Diabetes Clinic Database – why you need it and how to get it! - Peter Colman
• Diabetes Data, Quality, Audit and Benchmarking: [The Rise & Fall of ANDIAB 1993 – 2012] - Jeff Flack

• Diabetic Emergencies in a State-wide Australian Ambulance Service - Chin Yao Tan
• Anaerobic Exercise at Self-Report in Adults With Type 1 Diabetes Co-segregates With Increased Exercise Duration But Not With Hypoglycaemia: A Potential Role for Resistance Exercise in Limiting Hypoglycaemia - Agata Piotrowicz
• How problematic hypoglycaemia compromises quality of life - Christel Hendrieckx
• A lifetime perspective and risk of cognitive impairment in type 2 diabetes: Studies with the Fremantle Diabetes Study cohort - David G Bruce
• Diabetes, incident diabetes and impaired fasting glucose: 2-year effects on brain volume and cognition in the elderly. The Sydney Memory and Ageing Study - Katherine Samaras

Delegates involved in the poster discussion are required to stand by their poster on Wednesday 28th August from 1:30 PM – 2:00 PM. Presentations will be in 5 minute slots – 3 minutes to summarise research and 2 minutes to answer any questions.

Beta-Cell Chairperson - Kathryn Aston-Mourney

Complications Chairperson - Josephine Forbes

Immunology/Stem cells Chairperson - Charmaine Simeonovic

Adipose Tissue/Fatty Acids Chairperson - Andrew Hoy

Insulin Action Chairperson - Matthew Watt

Glucose Uptake/Homeostasis - Jiming Ye

• Id1 and Id3 regulate redox status and beta-cell survival under conditions of oxidative stress - Mohammed Bensellam
• Inflammation induced ZIP14 transporter upregulated in pancreatic islets of type 2 diabetic db/db mice - Mariea Bosco
• Glucose intolerance is a very early defect that predates profound hyperinsulinemia in high fat-fed obese foz/foz mice on the NOD.B10 background - Viviane Delghingaro-Augusto
• Deletion of β-cell ARNT (Aryl hydrocarbon Receptor Nuclear Translocator) Causes Islet Transplant Failure - Amit Lalwani
• LYSOSOMAL LIPID METABOLISM IS A NOVEL REGULATOR OF INSULIN SECRETION. - Gemma L Pearson
• Redox imbalance and endothelial DNA damage as early markers of atherosclerosis risk in prediabetes - Hayder Al-Aubaidy
• Altered NGAL Levels in Diabetic Kidney Disease: A Potential Marker for Tubular Damage - Ernuo Cheng
• Protection Against Progression of Non-Alcoholic Steatohepatitis (NASH) by Sitagliptin In Type 2 Diabetes  - Jing Ren
•  Effects of Aqueous Extract of Momordica charantia L. on Wound Healing in a Streptozotocin Induced Model of Type II Diabetes  - Alireza Rezaeizadeh
• Differential Profiles of Fenofibrate and Liraglutide on Pro-fibrotic and Pro-inflammatory Changes in a Murine Model of Diabetic Cardiomyopathy - Xiaoyu Wang
• Selected cell populations of the kidney present differing metabolic profiles which are further altered under hyperglycaemic conditions. - Micheal S Ward
• Reduced autoimmune diabetes incidence via glycotoxin lowering therapies is time dependent in an experimental diabetic mouse model - Danielle J Borg
• Role of pro-apoptotic molecule "bid" in immune-mediated human beta-cell death - Mugdha Joglekar
• Derivation, characterization and differentiation of human gallbladder-derived islet progenitor cells - Sarang Satoor
• Secreted proteins from the helminth parasite Fasciola hepatica modulate the immune environment to prevent autoimmune diabetes - Maria E Lund
• Deficiency in type I interferon signalling prevents the early interferon-gene signature in pancreatic islets but not type 1 diabetes in non-obese diabetic mice. - Hong Sheng Quah
• Adipose-derived Mesenchymal Cell Derivation, Characterization and Differentiation for potential use in cell replacement therapy for Diabetes - Michael Williams
• Deletion of Acetyl-CoA Carboxylase 2 (ACC2) does not alter insulin sensitivity despite increased fatty acid oxidation in 9-12 month old mice - Amanda Brandon
• Browning of human subcutaneous adipose tissue progenitor cells in lean and obese adults. - Andrew L Carey
• Adipose tissue and non-alcoholic steatohepatitis in high fat-fed foz/foz mice - Tenzin Dagpo
• Understanding a bug's life in the fat land - Holly D Kristensen
• Fatty acid oxidation and storage in the hypothalamic parenchyma of mice is limited by transport across the blood brain barrier - Vanessa R Haynes
• Integrated Systems Analysis of Insulin Resistance Reveals Cholesterol Homeostasis to be a Key Determinant of Insulin Sensitivity - Daniel Fazakerley
• THE MODULATION OF HEPATIC INSULIN ACTION AND LIPID METABOLISM BY PROTEIN KINASE C ISOFORMS - Mana (Bing Qing) Liao
• Diet is a more potent regulator of the total liver proteome than ageing - Christopher Meoli
• Amelioration of the ER-stress associated IRE-1 signalling pathway, but not the PERK pathway, correlates with restoration of insulin sensitivity in liver cells. - Juan C Molero
• Sodium-derived muscle insulin resistance is caused by a loss of microvascular insulin sensitivity that can be restored with ACE inhibition. - Dino Premilovac
• Optimization of conditional glycogen synthase deletion in skeletal muscle in mice. - Chrysovalantou E. Xirouchaki
• Kaempferol, a dietary flavonoid improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes - Khalid S Al-Numair
• NOS Inhibition Does Not Attenuate the Increase in Muscle Glucose Uptake During Contraction in Sprague Dawley Rats - Andrew C Betik
• Isolation and identification of a novel anti-diabetic compound of 3-hydroxymethyl xylitol (3-HMX) from Casearia esculenta (Roxb.) root, on key carbohydrate metabolic enzymes, lipid peroxides and antioxidants in streptozotocin-induced diabetic rats - Chandramohan Govindasamy
• NOS inhibition attenuates the increase in mouse skeletal muscle glucose uptake during contraction independently of nNOSμ - Yet Hoi Hong
• The Small Molecule Sophocarpidine as a Potential Novel Drug for Insulin Resistant State Targeting the Liver - Xiao-Yi Zeng

Chair: Alicia Jenkins

• Hepatic Steatosis, Dyslipoproteinaemia and Cardiometabolic Disease - Gerald F Watts
• Could HDL Therapies Have a Role in the Management of Diabetes? - Bronwyn A Kingwell
• Lipids in The Management of Diabetes - Richard O'Brien

• Glycemic Control and Treatment Satisfaction in Type 2 Diabetes: Basal Plus compared with Biphasic Insulin in the LANSCAPE Trial - Neale Cohen
• What really happens when patients with Type 2 diabetes (T2DM) are commenced on insulin –longitudinal changes in HbA1c from initiation to 4 years - from the Australian S4S-DINGO – Diabetes Informatics Group - David M Hoffman
• Predictors of good blood glucose control in people receiving biphasic insulin aspart 30 premix insulin: data from the A₁chieve study - Philip Home
• Improved glycaemic control without increased hypoglycaemia incidence and weight gain with insulin-vildagliptin combination therapy in Asian patients with type 2 diabetes - Richard Simpson
• Exenatide once weekly: Sustained glycaemic and weight control through 3 years compared with insulin glargine - Stephen Stranks

GP CME Eligible Session

• Management of Insulin Resistance and Beta Cell Dysfunction Late in Diabetes - Philip Home
• Early Management of insulin resistance in Type 2 Diabetes - Donald J Chisholm
• Late-stage Type 2 diabetes: can we target our therapies?  - Anthony Russell

• Differences in survival among multiple ethnic groups of Type 2 Diabetes in Australia - Turki Alharbi
• Recent diagnosis of diabetes mellitus is associated with mortality in older men. - Bu B Yeap
• All-cause and cardiovascular disease mortality in community-based patients with type 1 diabetes: The Fremantle Diabetes Study - Timothy ME Davis
• Queensland’s diabetic foot hospitalisation and amputation reduction:  Reducing the state of our foot hospital problem?  - Peter A Lazzarini
• THE DIABETES CARE PROJECT: A CLUSTER RANDOMISED TRIAL OF CARE FACILITATION AND STRUCTURED CLINICAL QUALITY IMPROVEMENT IN GENERAL PRACTICE IN 3 AUSTRALIAN STATES: BASELINE CLINICAL INDICATORS - Robyn McDermott
• DIABETES OUTREACH CLINIC FOR THE HOMELESS: A MODEL FOR IMPROVED CARE AND OUTCOMES? - Alexander Viardot

• Determinants of Insulin-Sensitive Obesity - Daniel LT Chen
• Retrospective study of Type 1 Diabetes in Indigenous Australians in the Top End, Northern Territory (NT) - Ni Ni Khin
• Maternal vitamin D level, glycaemic control and pregnancy outcomes: results from a multi-ethnic population of women with gestational diabetes mellitus in South-Western Sydney - Min Ling
• Time to steady state circulating insulin levels following insulin pump basal rate changes in type 1 diabetes - Sybil A McAuley
• Better Than International Average HbA1c Reductions in Australian Insulin Pump Services for Adults with Type-1 Diabetes - Daniel A Calandro
• Hypoglycaemia induced acceleration of gastric emptying is attenuated by exogenous GLP-1 in healthy subjects - Mark P Plummer

• ADEQUACY OF GLYCEMIC CONTROL IN DIABETIC DIALYSIS PATIENTS - A SINGLE CENTRE PROSPECTIVE OBSERVATIONAL STUDY USING CONTINUOUS GLUCOSE MONITORING. - TALIB ALJUMAILY
• “Change in all things is sweet”: the effects of antipsychotic switching on glycemic control and obesity in chronic schizophrenia. - Rosanne Arnoldy
• National in-hospital nutrition guidelines for people with diabetes. Process and outcomes from a National Diabetes Services Scheme / Australian Diabetes Society initiative. - Elizabeth Blanchard
• Telehealth Eye and Associated Medical Services Network [TEAMSnet] Study:  The Australian Implementation of the Comprehensive Diabetes Management Program [CDMP] - Sven-Erik Bursell
• Vitamin C deficiency and diabetic foot ulcers - Darshika J Christie-David
• A Curious Case of Insulin Resistance: Subcutaneous Insulin Resistance Syndrome - Darshika Christie-David
• Evaluation of the Roche cobas b 101 Point of Care instrument in the diagnosis of diabetic patients - Penelope J Cowley
• How the St Vincent's declaration can help mental health clinicians HeAL the physical burden of disease in severe mental illness - Katherine Samaras
• Peer-to-peer, multidisciplinary, process-focussed education increases GP confidence in using insulin therapy in type 2 diabetes (T2D)  - Gary Deed
• Increased placental FGF21 expression in gestational diabetes mellitus (GDM) - Marloes Dekker Nitert
• A Case Of Acute Painful Neuropathy Following Rapid Glycemic Control - Danijela Dravec
• Rates of distress and depression in people with diabetes in a regional general practice - Hanna E Grimson
• Monitoring the well-being of people with diabetes: how to translate guidelines into routine care? The NDSS National Development Program for Mental Health and Diabetes - Jennifer Halliday
• Visceral fat accumulation and metabolic risk factors of westernized overweight young males of Asian and European descent  - Mehrdad Heydari
• Similar socio-economic and educational status of adults with Type 1 Diabetes using insulin pumps and multiple daily insulin injections - Alicia J Jenkins
• Genetic susceptibility to type 2 diabetes influences the impact of obesity on heart rate variability     - Arthur B Jenkins
• Demystifying Type 2 Diabetes for GP registrars - Mark F Kennedy
• An Integrated Model for Diabetes Care in Socio-Economically Disadvantaged Regional Victoria.A partnership between the public and private sector. - Mark F Kennedy
• GLYCAEMIC PROFILE & ADVERSE OUTCOMES IN PATIENTS RECEIVING ENTERAL NUTRITION - Mani Manoharan
• Patients and prescribers in type 2 diabetes reported on attitudes and behaviours towards irregular basal insulin dosing in Australia - Margaret McGill
• A rare case of Fulminant type 1B Diabetes - Mohammad Mir
• Fremantle Diabetes Study: Longitudinal Apathy - Melinda Nelson
• Glucose and insulin infusion usage outcomes before and after institution of peri-operative glucose management guidelines in cardiothoracic patients. - J Y K Ng
• INTERNATIONAL DIABETES FEDERATION LIFE FOR A CHILD PROGRAM - Graham D Ogle
• ONCE-DAILY LIXISENATIDE AS ADD-ON TO BASAL INSULIN ± OADS IN PATIENTS WITH TYPE 2 DIABETES SELECTIVELY REDUCES POSTPRANDIAL HYPERGLYCEMIC DAYTIME EXPOSURE - David O'Neal
• AUSTRALASIAN DIABETES DATA NETWORK (ADDN): COLLABORATION FOR FUTURE RESEARCH - Helen Phelan
• Changing from a glargine-based insulin regimen to biphasic insulin aspart 30 in people with type 2 diabetes - Alana Philips
• Efficacy, safety and tolerability in type 1 diabetes of insulin aspart administered by InsuJet^TM compared to subcutaneous injection. - Anne T Reutens
• Keeping the Body in Mind: Early detection and prevention of diabetes in youth with psychosis - Simon Rosenbaum
• Acute autoimmune autonomic neuropathy in a type 1 diabetic - Manodhi Saranapala
• An Audit -The Current State of diabetes care at a major diabetes clinic in Sri Lanka. - Manodhi Saranapala
• A RARE CASE OF MAURIAC SYNDROME - Ali Sharafi
• What is the difference between adult patients with and without Cystic Fibrosis Related Diabetes in Tasmania? - Anne Sillars
• A Bitter-Sweet Lesson - Lisa Simmons
• Experiences from a multidisciplinary high risk foot clinic: a 6 month descriptive analysis - Himali Suwandarathne
• Case series: the effect of bariatric surgery on glycaemic control in patients with type 1 diabetes mellitus - Alice Tang
• The incretin effect is reduced or may be not altered in patients with chronic kidney disease - Jessie Teng
• Poor adherence to treatment guidelines of diabetic ketoacidosis leads to increased incidence of hypokalemia - Geetha Theverkalam
• An Audit on Hypoglycaemia - Aye Thin
• Comparative effects of prolonged and intermittent stimulation of the glucagon-like peptide-1 receptor on gastric emptying, glycaemia and insulinaemia - Mahesh M Umapathysivam
• Effectiveness and safety of vildagliptin compared with other oral antidiabetic drugs in patients with type 2 diabetes: results from EDGE, a large worldwide observational study. - Chad Woodcock

Delegates involved in the poster discussion are required to stand by their poster on Thursday 29th August from 2:00 PM – 2:30 PM. Presentations will be in 5 minute slots – 3 minutes to summarise research and 2 minutes to answer any questions.

Complications Chairperson - Elif I Ekinci

Diabetic Foot Chairperson - Pete Lazzarini

Type 1/Young DM Chairperson - Maria Craig

Glycaemia/Validity Chairperson - Gregory Fulcher

Trials Chairperson - Neale Cohen

Treatment/Prevention Chairperson - Stephen Stranks

• Screening for cirrhosis secondary to Non-alcoholic fatty liver disease (NAFLD) in a diabetes centre population using NAFLD Fibrosis Score (NFS): an externally-validated, simple, biomarker panel - Kathryn H Williams
• Long-term Intraindividual Variability in Albumin Excretion Rate in Patients with Type II Diabetes - Amanda Leong
• Hypoglycaemia and QT Prolongation: Detection by Simultaneous Holter and Continuous Glucose Monitoring - Angela Lee
• Relationship between 24h urinary sodium-to-potassium ratio with blood pressure and renin angiotensin aldosterone activity in people with diabetes - Renata Libianto
• Gender differences in cardiovascular risk factors and mortality in type 2 diabetes: The Fremantle Diabetes Study - Jocelyn Drinkwater
• "People with diabetes admitted for acute heart failure have prolonged hospital stay and under-recognised diastolic dysfunction" - Avinash Suryawanshi
• Effects of hospital acquired conditions on length of stay for diabetic patients. - Jayde E Cromarty
• Queensland’s foot ulcer database:  Monitoring the characteristics and outcomes of Queensland’s foot ulcers - Peter A Lazzarini
• Diabetes-related foot complications as a risk factor for osteoporosis - Qian Sun
• Introduction of an Interdisciplinary Diabetes Foot Service and the effect on Inpatient Length of Stay. - Michaela Barron
• The economic impact of peripheral arterial disease on lower extremity intervention in patients with and without diabetes mellitus. - Matthew Malone
• Rates of admission for diabetic foot ulceration, and amputation rates, 2002-2011, in the absence of a diabetes foot team - Duncan Topliss
• A meta-analysis of FDG PET/CT versus MRI in diagnosing diabetic foot osteomyelitis - Kevin Lee
• Diabetes health-service delivery: The experiences of young adults with Type 1 diabetes. - Janice Wiley
• Diabetes education: the experiences of young adults with Type 1 diabetes - Janice Wiley
• Alcohol and hypoglycaemia in type 1 diabetes - Sally Vindedzis
• Documenting Insulin Non-adherence in Young Adults with Type 1 Diabetes - Melanie Burkhardt
• The blood glucose response to moderate-intensity exercise is reproducible in individuals with type 1 diabetes on basal subcutaneous insulin infusion - Timothy W Jones
• A Prospective Assessment of Time Spent by Healthcare Professionals in Managing Diabetes Patients on Insulin Pumps in Australia - David O'Neal
• Application of a MODY calculator in diabetic Australians: The Fremantle Diabetes Study Phase II - Ashley E Makepeace
• The Effect of Specialist Referral on HbA1c: Data from the Australian S4S-DINGO – Diabetes Informatics Group - Teresa Lam
• Saxagliptin as add-on to metformin + sulfonylurea: Outcomes stratified by baseline A1C and patient characteristics - Robert G Moses
• Statin therapy and glycaemia in community-based patients with type 2 diabetes: The Fremantle Diabetes Study - Michelle England
• Investigating clinical inertia in the management of patients with type 2 diabetes mellitus in St Vincent’s Hospital Melbourne - Alice Hong
• Pre analytical glucose loss secondary to glycolysis in the first hour after venous sampling   - Huan Chan
• Ultrasonographic assessment of carotid bruits detected by an electronic stethoscope in community-based patients with type 2 diabetes: The Fremantle Diabetes Study Phase II - Arthur Knapp
• META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS OF LIXISENATIDE AS ADD-ON TO BASAL INSULIN ± OADs IN PATIENTS WITH TYPE 2 DIABETES MELLITUS - David O'Neal
• Response to dapagliflozin by baseline HbA1c in head-to-head comparisons - Shamik J Parikh
• Combined HbA1c and weight reduction is achieved more frequently with add-on dapagliflozin than add-on glipizide in patients with type 2 diabetes inadequately controlled on metformin - Shamik J Parikh
• Effectiveness and safety of starting insulin aspart premix therapy from different oral agents in routine clinical practice - John Miller
• Patients are more likely to reach A1c target at any given time during 26 weeks' treatment with liraglutide compared with both sitagliptin and exenatide - Mirella Daja
• Safety and efficacy of sitagliptin added to the combination of sulfonylurea and metformin in patients with type 2 diabetes mellitus and inadequate glycemic control - Stefan Orange
• Once daily liraglutide (1.2mg) vs twice daily exenatide (10ug) in the treatment of type 2 diabetes patients: a meta-analysis. - Mirella Daja
• Is Bariatric Surgery Being discussed as a Treatment option in appropriate patients with Type 2 Diabetes Mellitus? - Monika Fazekas
• Exenatide Therapy In An Indigenous Population with Type 2 Diabetes Aids in Substantial Weight Loss Even When The Glycaemic Response Fails: A Clinical Service Audit - A Traeger
• Metabolic outcomes in patients attending a Clozapine clinic - Christopher Muir
• High Quality Diet Associated with a Lower Risk of Type 2 Diabetes - Amani Alhazmi
• Total carbohydrate intake does not predict type2 diabetes risk in mid-age women from the Australian Longitudinal Study on Women's Health - Amani Alhazmi

GP CME Eligible Session

• The Fremantle Diabetes Study: The first 20 years  - Timothy Davis
• The epidemiology of childhood diabetes  - Maria Craig
• AusDiab - Jonathan Shaw

• METHOD VARIABILITY IN HbA1c DETERMINATIONS. RESULTS FROM RCPAQAP SURVEYS - Paul Williams
• ASSOCIATION BETWEEN POORLY CONTROLLED PRE-OPERATIVE DIABETES MELLITUS AND POST-OPERATIVE COMPLICATIONS - Arpudaswamy Kumar
• A randomised controlled trial investigating the effects of a low glycaemic index diet on pregnancy outcomes in women at high risk of gestational diabetes mellitus - Tania Markovic
• GDM among women who are overweight and obese: the effect of BMI category. - Kate E Martin
• Weight Loss is Good Medicine: a Randomised Trial of Gastric Band Surgery in Overweight but not Obese People with Type 2 Diabetes - John Wentworth
• Adipose tissue regulation of cell-mediated inflammation and 12-month outcomes after bariatric surgery in obesity and type 2 diabetes. - Katherine Samaras
• Weight loss following laparoscopic adjustable gastric banding prevents progression from impaired fasting glucose to diabetes - John Wentworth
• Increasing dietary protein improves 24-hour and post-prandial glucose concentrations - Rosemary M Hall

• Successful, cost effective interventions for improvement of lifestyle, prevention of weight gain and ultimately reduction of diabetes risk: a successful exemplar - Helena Teede
• Type 1 diabetes trials highlights   - Peter Colman
• Management of Type 2 Diabetes - Christopher Nolan
• Lipid lowering strategies in diabetes - Tony Keech

• High fat diet induced cardiac insulin resistance occurs independently of myocardial lipotoxicity and without impairments in the insulin signaling cascade. - Darren C Henstridge
• Multigeneration Undernutrition, Central adiposity and nutrient transition - a Thrifty Jerry - Anandwardhan Hardikar
• HDL MODULATES GLUCOSE METABOLISM IN CARDIOMYOCYTES - Sarah E Heywood
• Maternal high fat diet, in absence of obesity, causes insulin resistance and alters skeletal muscle oxidative phosphorylation in adult rat offspring - Celine Latouche
•  Identifying Type 2 Diabetes Susceptibility Loci Using The "Gene Mine" - Salvatore P Mangiafico
• Fructose Diet-Induced ER Stress Involves Suppressed Autophagy via the mTOR Signalling Pathway - Hao Wang